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Full‐dose ifosfamide can be safely administered to outpatients
Author(s) -
Meazza Cristina,
Bisogno Gianni,
Casanova Michela,
Zanetti Ilaria,
Carli Modesto,
Ferrari Andrea
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20958
Subject(s) - mesna , ifosfamide , medicine , anesthesia , chemotherapy , surgery , etoposide
This report compares a traditional full‐dose ifosfamide administration modality (24‐hr hyperhydration and mesna infusion) with a simplified 9‐hr hyperhydration and mesna infusion for use in outpatients. Acute ifosfamide toxicity was the same, suggesting that ifosfamide could be safely administered to outpatients, reducing the currently‐recommended prolonged hyperhydration and mesna uroprotection, thus resulting in shorter hospital stays and consequently lower costs. Pediatr Blood Cancer 2008;50:375–378. © 2006 Wiley‐Liss, Inc.