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Precursor B‐cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis
Author(s) -
O'Brien Maureen M.,
LeeKim Youngna,
George Tracy I.,
McClain Kenneth L.,
Twist Clare J.,
Jeng Michael
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20950
Subject(s) - hemophagocytic lymphohistiocytosis , medicine , malignancy , lymphoblastic leukemia , immunology , leukemia , disease , pathology
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK‐cell lymphoid neoplasms. HLH with B‐cell malignancies is less common and HLH has rarely been described in association with precursor B‐cell acute lymphoblastic leukemia (B‐ALL). We report three cases of HLH associated with B‐ALL and review 17 cases of ALL‐associated HLH previously reported in the literature. Pediatr Blood Cancer 2008;50:381–383. © 2006 Wiley‐Liss, Inc.