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Radiotherapy in the multimodal treatment of extrarenal extracranial malignant rhabdoid tumors
Author(s) -
Puri Dev R.,
Meyers Paul A.,
Kraus Dennis H.,
LaQuaglia Michael P.,
Wexler Leonard H.,
Wolden Suzanne L.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20947
Subject(s) - medicine , blood cancer , radiation therapy , chemotherapy , multimodal therapy , malignant disease , disease , cancer , surgery , radiology , oncology
Extrarenal extracranial malignant rhabdoid tumors (MRT) are extremely rare and typically lethal. No consensus exists on an optimal treatment approach, and, in particular, the role of radiation therapy (RT) is poorly defined. We report on three children who underwent multimodality treatment including surgery, chemotherapy (CMT), and RT. Two of these patients are alive and without evidence of disease 6½ and 7 years after diagnosis and one has expired. Our limited experience suggests that RT in the setting of CMT and surgery has the potential to prolong survival with acceptable toxicity, but outcomes are inconsistent and further study is necessary. Pediatr Blood Cancer 2008;50:167–169. © 2006 Wiley‐Liss, Inc.