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Stage III cystic partially differentiated nephroblastoma recurring after nephrectomy and chemotherapy
Author(s) -
Baker Jillian Margaret,
Viero Sandra,
Kim Peter C.,
Grant Ronald M.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20930
Subject(s) - medicine , chemotherapy , nephrectomy , blood cancer , stage (stratigraphy) , wilms' tumor , disease , surgery , pathology , cancer , kidney , paleontology , biology
Cystic partially differentiated nephroblastoma (CPDN) has low malignant potential. We report a 1‐year‐old with stage III CPDN of the right kidney that recurred following radical nephrectomy and chemotherapy. There was evidence of tumor spillage pre‐operatively and intra‐operatively. During chemotherapy the disease recurred in the omentum and the peritoneum. Pathology of the recurrent resected cysts revealed a more differentiated biphasic tumor without blastemal elements. It appears that spillage of CPDN in our patient led to dissemination of disease. Chemotherapy failed to prevent recurrence but only mature elements were present following this treatment. The intensity of therapy required to treat CPDN remains undefined. Pediatr Blood Cancer 2008;50:129–131. © 2006 Wiley‐Liss, Inc.