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Paediatric Kikuchi–Fujimoto disease: A benign cause of fever and lymphadenopathy
Author(s) -
Lazzareschi Ilaria,
Barone Giuseppe,
Ruggiero Antonio,
Liotti Lucia,
Maurizi Palma,
Larocca Luigi Maria,
Riccardi Riccardo
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20918
Subject(s) - medicine , cervical lymphadenopathy , disease , etiology , lymphoma , dermatology , fever of unknown origin , cervical lymph nodes , pathology , surgery , cancer , metastasis
Kikuchi–Fujimoto disease (KFD) is a rare and benign disease that typically affects the cervical lymph nodes. Its aetiology is unknown and a role of the autoimmune system in the pathogenesis is hypothesized. This self‐limiting disease is often confused with malignancies. No specific management is generally required but long‐term follow‐up should be planned despite the low risk of recurrence, as recurrences have been described many years after the first episode and there is a high risk of development of an autoimmune disease or even lymphoma. We review the clinical and histological features of KFD and report an unusual case presenting with cervical and supraclavicular lymphadenopathy, and persistent fever. Pediatr Blood Cancer 2008;50:119–123. © 2006 Wiley‐Liss, Inc.