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Stem cell transplantation for polycythemia vera
Author(s) -
Reinhard Harald,
Klingebiel Thomas,
Lang Peter,
Bader Peter,
Niethammer Dietrich,
Graf Norbert
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20906
Subject(s) - medicine , busulfan , phlebotomy , polycythemia vera , transplantation , cyclophosphamide , gastroenterology , stem cell , surgery , hematopoietic stem cell transplantation , pediatrics , chemotherapy , biology , genetics
Polycythemia vera (PV) is a rare disease in children. A 9‐year‐old male was diagnosed following laboratory results acquired because of an acute appendicitis. Regular phlebotomy was performed for over 2 years followed by α‐interferon treatment. At the age of 12 years, HLA‐matched unrelated stem cell transplantation including T‐cell depletion was done. The conditioning regimen consisted of busulfan, cyclophosphamide, and ATG. Chimerism was monitored during the whole post‐transplant period. A single dose of donor T ‐lymphocytes was given at month 3. One year after transplantation, chimerism was complete. The patient is in complete remission and shows no signs of transplant‐related morbidity at month 78. Pediatr Blood Cancer 2008;50:124–126. © 2006 Wiley‐Liss, Inc.