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Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia
Author(s) -
Kitchen Brenda J.,
Boxer Laurence A.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20902
Subject(s) - autoimmune hemolytic anemia , medicine , immunology , concomitant , neutropenia , cytotoxic t cell , anemia , leukemia , hemolytic anemia , methotrexate , antibody , chemotherapy , biology , biochemistry , in vitro
Abstract We describe a female with a history of autosomal recessive hyper‐IgM (HIGM) syndrome along with a history of autoimmune hemolytic anemia and intermittent lymphadenopathy. She subsequently developed neutropenia, lymphocyostosis and mild thrombocytopenia. Flow cytometry of the peripheral blood revealed the presence of a marked predominance of cytotoxic T lymphocytes, shown to be clonal, with concomitant natural killer (NK) antigen expression. She responded to weekly methotrexate therapy. Pediatr Blood Cancer 2008;50:142–145. © 2006 Wiley‐Liss, Inc.