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Precursor B lymphoblastic leukemia 32 months after local therapy for a primary extramedullary myeloid cell tumor
Author(s) -
Szinnai Gabor,
Cogliatti Sergio B.,
Avoledo Pierino,
Dirnhofer Stephan,
Schmid Ulrico,
Kühne Thomas
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20789
Subject(s) - medicine , lymphoblastic leukemia , myeloid leukemia , cancer research , myeloid , primary (astronomy) , leukemia , oncology , physics , astronomy
A primary extramedullary myeloid cell tumor (pEMT) of an inguinal lymph node was completely excised without subsequent anti‐tumor therapy in a 6‐year‐old child. Clinical observation and monitoring of blood and bone marrow (BM) did not reveal any pathologic results before 32 months, when a precursor B lymphoblastic leukemia was diagnosed. Identical T‐cell receptor gamma rearrangement in nodal pEMT and in precursor B lymphoblastic leukemia in BM indicates a clonal relationship of these two tumors. Pediatr Blood Cancer 2007;49:1039–1046. © 2006 Wiley‐Liss, Inc.