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Adolescents with acute lymphoblastic leukaemia: Emerging from the shadow of paediatric and adult treatment protocols
Author(s) -
Ramanujachar Ramya,
Richards Sue,
Hann Ian,
Webb David
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20776
Subject(s) - medicine , blood cancer , pediatrics , referral , clinical trial , young adult , lymphoblastic leukemia , cancer , family medicine , leukemia
Adolescents and young adults (AYA) with acute lymphoblastic leukaemia (ALL) constitute a distinct population from children and older adults. Based on patterns of referral, they may be treated by either paediatric or adult oncologists. As a group, AYA with ALL have a worse survival and event‐free survival (EFS) compared to that achieved by younger children. A systematic review of all published clinical trials, which provide data on treatment and outcome of adolescents with ALL, has been summarised in an effort to determine whether they should be treated on paediatric or adult type protocols. Adolescents appear to have a consistent survival advantage when treated on paediatric regimens. Pediatric Blood Cancer 2006;47:748–756. © 2006 Wiley‐Liss, Inc.