Premium
Collection, storage, and infusion of stem cells in children with high‐risk neuroblastoma: Saving for a rainy day
Author(s) -
Grupp Stephan A.,
Cohn Susan L.,
Wall Donna,
Reynolds C. Patrick
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20769
Subject(s) - medicine , neuroblastoma , blood cancer , apheresis , haematopoiesis , stem cell , cd34 , pediatric oncology , pediatric cancer , disease , oncology , cancer , platelet , genetics , biology , cell culture
In this position statement issued by the Hematopoietic Stem Cell Transplant Discipline and the Neuroblastoma Disease Committee of the Children's Oncology Group (COG), we address the feasibility and advisability of collecting sufficient peripheral blood stem cells in neuroblastoma patients to both support the planned initial HDC/SCR procedure(s) as well as allow for therapies, potentially utilized after a recurrence of disease, that may require PBSC support. An additional aliquot of cells for potential subsequent therapies could be collected at the time of the initial PBSC apheresis episode, by any of extending the collection time, extending the apheresis episode by a single day, or cryopreserving a separate aliquot from collections in which large numbers of CD34+ cells are collected. Pediatr Blood Cancer © 2006 Wiley‐Liss, Inc.