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Lethal double infection with Acremonium strictum and Aspergillus fumigatus during induction chemotherapy in a child with ALL
Author(s) -
Foell J. L.,
Fischer M.,
Seibold M.,
BorneffLipp M.,
Wawer A.,
Horneff G.,
Burdach S.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20756
Subject(s) - aspergillus fumigatus , acremonium , neutropenia , caspofungin , medicine , aspergillosis , voriconazole , amphotericin b , mycosis , chemotherapy , immunology , induction chemotherapy , aspergillus , microbiology and biotechnology , biology , antifungal , dermatology , botany
Fungal infections are a major cause of morbidity and mortality in patients during chemotherapeutic treatments and malignant hematologic disease. We present a case of a double fungal infection with disseminated Acremonium strictum ( A. strictum ) and pulmonary Aspergillus fumigatus ( A. fumigatus ) and its rapid clinical course. A 17‐year‐old boy with prolonged neutropenia developed a disseminated fungal infection during induction chemotherapy of his acute lymphoblastic leukemia. The infection was rapidly lethal despite neutrophil recovery and early antifungal combination therapy with amphotericin B and caspofungin. Since there are only a few reports about invasive Acremonium infections, we present this case with regard to differences in the clinic pathologic features of Aspergillosis and other opportunistic fungal infections due to Fusarium or Acremonium species. Pediatr Blood Cancer 2007;49:858–861. © 2006 Wiley‐Liss, Inc.