Temporary diabetes mellitus secondary to a primary pancreatic Burkitt lymphoma | Zendy

Meier Constance | Zendy; Kapellen Thomas | Zendy; Tröbs Ralph B. | Zendy; Hirsch Wolfgang | Zendy; Parwaresch Reto | Zendy; Kiess Wieland | Zendy; Körholz Dieter | Zendy

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Temporary diabetes mellitus secondary to a primary pancreatic Burkitt lymphoma

Author(s) -

Meier Constance,

Kapellen Thomas,

Tröbs Ralph B.,

Hirsch Wolfgang,

Parwaresch Reto,

Kiess Wieland,

Körholz Dieter

Publication year - 2006

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.20752

Subject(s) - medicine , pancreas , diabetes mellitus , lymphoma , endocrine system , pathology , gastroenterology , endocrinology , hormone

Primary pancreatic lymphoma (PPL) is a rare form of extranodal lymphoma. So far, only in adults has a coincidence with diabetes mellitus (DM) been described. We report a nearly 9‐year‐old German boy presenting with a Burkitt lymphoma associated with a temporary insulin‐dependent DM and exocrine insufficiency of the pancreas. After the patient went into remission, a spontaneous recovery of the endocrine pancreatic function was observed. On immunophenotyping, the lymphoma cells revealed expression of FasL suggesting a potentially apoptotic effect on pancreatic tissue. Beta cell impairment may have been caused by FasL resembling autoimmune diabetes. Pediatr Blood Cancer © 2006 Wiley‐Liss, Inc.

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