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Temporary diabetes mellitus secondary to a primary pancreatic Burkitt lymphoma
Author(s) -
Meier Constance,
Kapellen Thomas,
Tröbs Ralph B.,
Hirsch Wolfgang,
Parwaresch Reto,
Kiess Wieland,
Körholz Dieter
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20752
Subject(s) - medicine , pancreas , diabetes mellitus , lymphoma , endocrine system , pathology , gastroenterology , endocrinology , hormone
Primary pancreatic lymphoma (PPL) is a rare form of extranodal lymphoma. So far, only in adults has a coincidence with diabetes mellitus (DM) been described. We report a nearly 9‐year‐old German boy presenting with a Burkitt lymphoma associated with a temporary insulin‐dependent DM and exocrine insufficiency of the pancreas. After the patient went into remission, a spontaneous recovery of the endocrine pancreatic function was observed. On immunophenotyping, the lymphoma cells revealed expression of FasL suggesting a potentially apoptotic effect on pancreatic tissue. Beta cell impairment may have been caused by FasL resembling autoimmune diabetes. Pediatr Blood Cancer © 2006 Wiley‐Liss, Inc.