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Intraocular Langerhans cell histiocytosis in a neonate resulting in bilateral loss of vision
Author(s) -
Boztug Kaan,
FrimpongAnsah Kwabena,
Nanduri Vasanta Rao,
Lawson Joanna,
RussellEggitt Isabelle,
Brock Penelope
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20714
Subject(s) - langerhans cell histiocytosis , medicine , histiocytosis , uvea , rare disease , dermatology , disease , eye disease , ophthalmology , pathology
Intraocular involvement in Langerhans cell histiocytosis (LCH) is rare. We describe the case of a neonate with congenital disseminated LCH involving skin, liver, spleen, and intraocular structures including uvea and retina. Early and aggressive treatment according to the LCH‐II treatment protocol was administered and resulted in remission of the disease. However, despite close follow‐up and additional local treatment, involvement of intraocular structures resulted in severe long‐term ophthalmological sequelae including complete bilateral loss of vision. Pediatr Blood Cancer 2006; 47:633–635. © 2006 Wiley‐Liss, Inc.