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Favorable histology, MYCN‐amplified 4S neonatal neuroblastoma
Author(s) -
Chan Edward L.,
Harris Richard E.,
Emery Kathleen H.,
Gelfand Michael J.,
Collins Margaret H.,
Gruppo Ralph A.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20705
Subject(s) - medicine , neuroblastoma , histology , oncology , cancer research , pathology , genetics , biology , cell culture
We report a neonate with 4S neuroblastoma and MYCN amplification, but favorable Shimada histology, successfully treated with chemotherapy and 13‐ cis ‐retinoic acid without stem cell transplantation. MYCN amplification in neuroblastoma is usually associated with unfavorable Shimada histology; the presence of these features in infants with 4S disease confers a poor prognosis. A small number of infants with 4S neuroblastoma and MYCN amplification have favorable Shimada histology. In this subgroup of infants, histopathology may be equally important in predicting outcome. © 2005 Wiley‐Liss, Inc.