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Prophylactic treatment of a small child with severe factor VII deficiency using repeat dosing from a single vial of recombinant activated factor VII
Author(s) -
Michaels Lisa A.,
Philipp Claire S.,
Eisele Joan,
Pappas Heather,
Saidi Parvin
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20688
Subject(s) - medicine , vial , dosing , recombinant dna , surgery , pharmacology , chromatography , biochemistry , chemistry , gene
We report our experience with a small child with severe factor VII deficiency and a history of frequent and spontaneous life‐threatening hemorrhage. The patient has received several years of successful prophylactic treatment with an every 3‐day infusion program in which she receives recombinant activated factor VII (rVIIa) using multiple doses from a single reconstituted vial over a 72‐hr period. Comparison is made to prophylactic treatment in this same patient using plasma‐derived factor VII (PDVII) using a prothrombin complex concentrate (PCC). Pediatr Blood Cancer 2007;49:736–739. © 2005 Wiley‐Liss, Inc.