Response to vinorelbine and low‐dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor | Zendy

Ferrari Andrea | Zendy; Grosso Federica | Zendy; Stacchiotti Silvia | Zendy; Meazza Cristina | Zendy; Zaffignani Elena | Zendy; Marchianò Alfonso | Zendy; Casanova Michela | Zendy

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Response to vinorelbine and low‐dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

Author(s) -

Ferrari Andrea,

Grosso Federica,

Stacchiotti Silvia,

Meazza Cristina,

Zaffignani Elena,

Marchianò Alfonso,

Casanova Michela

Publication year - 2007

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.20682

Subject(s) - medicine , desmoplastic small round cell tumor , vinorelbine , cyclophosphamide , regimen , oncology , chemotherapy , refractory (planetary science) , rhabdomyosarcoma , radiology , sarcoma , pathology , physics , astrobiology , cisplatin

We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low‐dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy. Pediatr Blood Cancer 2007;49:864–866. © 2005 Wiley‐Liss, Inc.

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