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Response to vinorelbine and low‐dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor
Author(s) -
Ferrari Andrea,
Grosso Federica,
Stacchiotti Silvia,
Meazza Cristina,
Zaffignani Elena,
Marchianò Alfonso,
Casanova Michela
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20682
Subject(s) - medicine , desmoplastic small round cell tumor , vinorelbine , cyclophosphamide , regimen , oncology , chemotherapy , refractory (planetary science) , rhabdomyosarcoma , radiology , sarcoma , pathology , physics , astrobiology , cisplatin
We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low‐dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy. Pediatr Blood Cancer 2007;49:864–866. © 2005 Wiley‐Liss, Inc.