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Hepatoblastoma in a child with neurofibromatosis type I
Author(s) -
Uçar Canan,
Çalışkan Ümran,
Toy Hatice,
Günel Engin
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20663
Subject(s) - hepatoblastoma , medicine , neurofibromatosis , neurofibromatosis type i , pathology , macrocephaly , oncology
A major hallmark of NF1 is the development of benign tumors, including peripheral neurofibromas, plexiform neurofibromas, gliomas of the optic tract, other low grade gliomas, and pheochromocytomas. Hepatoblastoma have not been previously reported in patients with neurofibromatosis type 1. We present a case of a 9‐month‐old boy diagnosed with both hepatoblastoma and neurofibromatosis type 1. Hepatoblastoma occurs in association with several well‐described cancer predisposition syndromes, including familial adenomatous polyposis, Beckwith–Wiedemann syndrome, Li‐Fraumeni syndrome, trisomy 18, and glycogen storage disease type I. This paper describes a case of hepatoblastoma diagnosed in association with neurofibromatosis type 1. Pediatr Blood Cancer 2007;49:357–359. © 2005 Wiley‐Liss, Inc.