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Fatal pneumonitis in children with metastatic rhabdomyosarcoma following whole lung radiotherapy and sequential epirubicin
Author(s) -
Prestwich R.J.,
Picton S.V.,
Glaser A.,
Taylor R.E.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20660
Subject(s) - medicine , epirubicin , radiation therapy , pneumonitis , chemotherapy , rhabdomyosarcoma , radiation pneumonitis , complication , lung cancer , lung , oncology , surgery , sarcoma , pathology , cyclophosphamide
Interstitial pneumonitis is a recognized complication following whole lung radiotherapy. We report two cases in which fatal pneumonitis appeared to be precipitated by the administration of epirubicin‐containing combination chemotherapy within 7 weeks of completion of whole lung radiotherapy. These cases highlight a potentially fatal interaction between radiotherapy and modern chemotherapy regimens. Pediatr Blood Cancer 2007;48:586–590. © 2005 Wiley‐Liss, Inc.