Fatal pneumonitis in children with metastatic rhabdomyosarcoma following whole lung radiotherapy and sequential epirubicin | Zendy

Prestwich R.J. | Zendy; Picton S.V. | Zendy; Glaser A. | Zendy; Taylor R.E. | Zendy

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Fatal pneumonitis in children with metastatic rhabdomyosarcoma following whole lung radiotherapy and sequential epirubicin

Author(s) -

Prestwich R.J.,

Picton S.V.,

Glaser A.,

Taylor R.E.

Publication year - 2007

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.20660

Subject(s) - medicine , epirubicin , radiation therapy , pneumonitis , chemotherapy , rhabdomyosarcoma , radiation pneumonitis , complication , lung cancer , lung , oncology , surgery , sarcoma , pathology , cyclophosphamide

Interstitial pneumonitis is a recognized complication following whole lung radiotherapy. We report two cases in which fatal pneumonitis appeared to be precipitated by the administration of epirubicin‐containing combination chemotherapy within 7 weeks of completion of whole lung radiotherapy. These cases highlight a potentially fatal interaction between radiotherapy and modern chemotherapy regimens. Pediatr Blood Cancer 2007;48:586–590. © 2005 Wiley‐Liss, Inc.

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