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Recurrent ependymoma treated with high‐dose tamoxifen in a peripubertal female: Impact on tumor and the pituitary–ovarian axis
Author(s) -
Yoffe Rona,
Khakoo Yasmin,
Dunkel Ira J.,
Souweidane Mark,
Lis Eric,
Sklar Charles
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20647
Subject(s) - medicine , tamoxifen , ependymoma , ovarian cancer , oncology , childhood cancer , endocrinology , cancer , pathology , breast cancer
Due to high rates of recurrence, the prognosis of childhood ependymoma remains guarded. Anecdotal evidence suggests that tamoxifen may have a role in the treatment of these tumors. We present a case of a child with recurrent ependymoma treated with tamoxifen who showed tumor regression on two separate occasions. However, treatment with tamoxifen resulted in the development of large ovarian cysts associated with supraphysiological plasma concentrations of estradiol. Pediatr Blood Cancer 2007;49:758–760. © 2005 Wiley‐Liss, Inc.