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Remission of aplastic anemia induced by treatment for Graves disease in a pediatric patient
Author(s) -
Das Prabodh Kumar,
Wherrett Diane,
Dror Yigal
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20640
Subject(s) - medicine , aplastic anemia , autoimmunity , disease , immunology , graves' disease , blood cancer , anemia , haematopoiesis , immunity , cancer , autoimmune disease , pediatrics , gastroenterology , immune system , stem cell , bone marrow , biology , genetics
Abstract Aplastic anemia (AA) is mediated by T‐cell autoimmunity in the majority of cases; it is rare and mostly idiopathic in children. We describe a child, who developed AA following Graves' disease which could not be attributed to antithyroid drugs. We hypothesized that both diseases were caused by similar autoimmune process. We monitored the blood counts and did not administer any conventional treatment for AA assuming that the existing anti‐ hematopoietic stem cell humoral and cellular immunity might subside with induction of remission of Grave's disease. The child went into complete remission with the treatment of the Graves' disease. Pediatr Blood Cancer 2007;49:210–212. © 2007 Wiley‐Liss, Inc.