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Vincristine sulfate as a possible cause of optic neuropathy
Author(s) -
WeisfeldAdams James D.,
Dutton Gordon N.,
Murphy Dermot M.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20638
Subject(s) - medicine , vincristine , discontinuation , optic neuropathy , neurofibromatosis , visual acuity , etiology , blood cancer , chemotherapy , optic nerve , surgery , pathology , ophthalmology , cancer , cyclophosphamide
Abstract A 6‐year‐old boy with skin lesions suggestive of neurofibromatosis developed a frontotemporal primitive neuroectodermal tumor and was subsequently treated with surgery, craniospinal irradiation, and chemotherapy. After the sixth cycle of treatment with vincristine sulfate, 9 months after diagnosis, the child developed a rapidly progressive bilateral deterioration in visual acuity. Retinal appearances were consistent with optic neuropathy. Gene studies for neurocutaneous syndromes were negative. Brain imaging at this time showed no tumor progression, and in the absence of other etiologies, we implicate vincristine as a probable cause. Discontinuation of this particular agent has allowed bilateral improvement in visual acuity. Pediatr Blood Cancer 2007;48:238–240. © 2006 Wiley‐Liss, Inc.