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Endodermal sinus tumor of the vagina
Author(s) -
Terenziani Monica,
Spreafico Filippo,
Collini Paola,
Meazza Cristina,
Massimino Maura,
Piva Luigi
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20636
Subject(s) - medicine , endodermal sinus tumor , vagina , regimen , chemotherapy , lesion , germ cell tumors , surgery
Malignant germ cell tumors of the vagina represent a critical site for local treatment. We report on our experience with two vaginal endodermal sinus tumors. Treatment with PEB regimen induced both tumor regression and α fetoprotein normalization. One patient had a residual lesion that was biopsed twice and no viable tumor cells were ever found. Both patients remained alive and disease‐free, without having had surgical procedures except for biopsies. Platinum‐based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors. Pediatr Blood Cancer 2007;48:577–578. © 2005 Wiley‐Liss, Inc.