Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide | Zendy

Khaw Seong L. | Zendy; Downie Peter A. | Zendy; Waters Keith D. | Zendy; Ashley David M. | Zendy; Heath John A. | Zendy

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Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide

Author(s) -

Khaw Seong L.,

Downie Peter A.,

Waters Keith D.,

Ashley David M.,

Heath John A.

Publication year - 2007

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.20617

Subject(s) - mesna , medicine , cyclophosphamide , hemorrhagic cystitis , adverse effect , dermatology , disease , hypersensitivity reaction , immunology , chemotherapy , ifosfamide , etoposide

Mesna is widely used for the prevention of cyclophosphamide‐related hemorrhagic cystitis. It has been associated with hypersensitivity‐like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna adminstration and discuss possible mechanisms and management issues. Pediatr Blood Cancer 2007;49:341–343. © 2005 Wiley‐Liss, Inc.

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