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Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide
Author(s) -
Khaw Seong L.,
Downie Peter A.,
Waters Keith D.,
Ashley David M.,
Heath John A.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20617
Subject(s) - mesna , medicine , cyclophosphamide , hemorrhagic cystitis , adverse effect , dermatology , disease , hypersensitivity reaction , immunology , chemotherapy , ifosfamide , etoposide
Abstract Mesna is widely used for the prevention of cyclophosphamide‐related hemorrhagic cystitis. It has been associated with hypersensitivity‐like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna adminstration and discuss possible mechanisms and management issues. Pediatr Blood Cancer 2007;49:341–343. © 2005 Wiley‐Liss, Inc.