Premium
Reversible posterior leukoencephalopathy syndrome in children undergoing induction therapy for acute lymphoblastic leukemia
Author(s) -
Norman Jennifer K.,
Parke Julie T.,
Wilson Don A.,
McNallKnapp René Y.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20597
Subject(s) - medicine , leukoencephalopathy , lymphoblastic leukemia , blood cancer , magnetic resonance imaging , pediatrics , chemotherapy , induction chemotherapy , acute leukemia , altered mental status , cancer , leukemia , radiology
We present three cases of children with acute neurologic changes while undergoing induction chemotherapy for acute lymphoblastic leukemia (ALL). These cases fall into the spectrum of reversible posterior leukoencephalopathy syndrome (RPLS), including abrupt alterations in mental status, headache, seizures, visual changes, hypertension, and characteristic findings on magnetic resonance imaging. Although the underlying mechanism of RPLS is still under investigation, the appropriate treatment and management of the acute event is becoming clearer. Early treatment of hypertension, control of seizure activity, and withdrawal of inciting agents can lead to rapid reversal of symptoms and return to baseline functioning. Pediatr Blood Cancer 2007;49:198–203. © 2005 Wiley‐Liss, Inc.