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Acute lymphoblastic leukemia presenting in fulminant hepatic failure
Author(s) -
Litten Jason B.,
Rodríguez Maria M.,
Maniaci Vincenzo
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20544
Subject(s) - medicine , fulminant hepatic failure , hepatic encephalopathy , fulminant hepatitis , liver function tests , clofarabine , infiltration (hvac) , leukemia , hepatitis , gastroenterology , pathology , cytarabine , liver transplantation , transplantation , cirrhosis , physics , thermodynamics
A previously healthy 4‐year‐old boy was admitted because of acute liver failure. He was icteric, lethargic, had elevated ammonia and abnormal liver function tests. Serology was negative for viral hepatitis. There was no history of hepatotoxic drugs. Family history was unremarkable. The child was taken to the operating room for a living‐related hepatic transplant. Frozen section showed massive hepatic leukemic infiltration and hepatocellular necrosis. Bone marrow aspiration confirmed the diagnosis of acute lymphoblastic leukemia (ALL). Transplant was withheld and chemotherapy was attempted. He died the following day due to systemic leukemic infiltration, cerebral edema, and severe anoxic ischemic encephalopathy. Pediatric Blood Cancer 2006;47:842–845. © 2005 Wiley‐Liss, Inc.