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T‐cell acute lymphoblastic leukemia relapsing as acute myelogenous leukemia
Author(s) -
Mantadakis Elpis,
Danilatou Vassiliki,
Stiakaki Eftichia,
Paterakis George,
Papadhimitriou Stefanos,
Kalmanti Maria
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20543
Subject(s) - medicine , lymphoblastic leukemia , leukemia , cancer research , immunology , oncology
We present the unusual case of a 16‐year‐old girl with T‐cell acute lymphoblastic leukemia (ALL) with an early thymocyte immunophenotype without myeloid markers, who after 13 months of complete hematological remission relapsed as acute myelogenous leukemia (AML) with minimal differentiation and died of her disease. Whether the AML represented a relapse with lineage switch of the original immature T‐cell clone or a new secondary malignancy, could not be proven due to the absence of molecular or clonal markers. This report suggests that a subset of CD7+ T‐cell leukemias without mature T‐cell antigens (CD4‐, CD8‐) are minimally differentiated and can relapse as AML. Pediatr Blood Cancer 2007;48:354–357. © 2005 Wiley‐Liss, Inc.