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Two infants with life‐threatening diffuse neonatal hemangiomatosis treated with cyclophosphamide
Author(s) -
Gottschling Sven,
Schneider G.,
Meyer S.,
Reinhard H.,
DillMueller D.,
Graf N.
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20522
Subject(s) - medicine , cyclophosphamide , coagulopathy , chemotherapy , consumptive coagulopathy , surgery , pediatrics
Diffuse neonatal hemangiomatosis (DNH) is a rare, frequently fatal disorder characterized by multiple cutaneous and visceral hemangiomas. Complications include high‐output cardiac failure, hemorrhage, hepatic failure, and consumption coagulopathy. We present two cases of neonates with DNH. We prescribed cyclophosphamide after failure of corticosteroids. Cyclophosphamide induced a fast regression of the lesions with no side effects in both infants. We were able to stop treatment after 3–4 courses of cyclophosphamide in both infants because of the excellent response. Cyclophosphamide seems to be a safe and effective treatment in patients suffering from life‐threatening DNH unresponsive to corticosteroids. Pediatr Blood Cancer 2006;46:239–242. © 2005 Wiley‐Liss, Inc.