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A second leiomyosarcoma in the urinary bladder of a child with a history of retinoblastoma 12 years following partial cystectomy
Author(s) -
Brucker Benjamin,
Ernst Linda,
Meadows Anna,
Zderic Stephen
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20506
Subject(s) - medicine , leiomyosarcoma , cystectomy , dysuria , retinoblastoma , urinary bladder , urinary diversion , rhabdomyosarcoma , urinary system , surgery , urology , bladder cancer , sarcoma , pathology , cancer , biochemistry , chemistry , gene
This case describes a twin with bilateral retinoblastoma who developed leiomyosarcoma of the bladder at age 17 and again at 39. At 17‐years of age she was diagnosed with a leiomyosarcoma of the bladder after presenting with recurrent urinary tract infections, hematuria, and dysuria. She was treated with partial cystectomy. After a 12‐year disease‐free interval, she was diagnosed with a second leiomyosarcoma of the bladder. This case supports the relationship between the genetic form of retinoblastoma and leiomyosarcoma and illustrates the necessity for extensive follow‐up and well‐defined treatment of secondary neoplasms. © 2006 Wiley‐Liss, Inc.