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Paraneoplastic syndrome and intrathoracic Castleman disease
Author(s) -
Hung IouJih,
Lin JainnJim,
Yang ChaoPing,
Hsueh Chuen
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20499
Subject(s) - medicine , paraneoplastic pemphigus , thrombocytosis , hypergammaglobulinemia , castleman disease , biopsy , dermatology , anemia , skin biopsy , disease , pathology , radiology , platelet , antibody , immunology , autoantibody
We report two cases of intrathoracic Castleman disease presenting with paraneoplastic syndrome. Patient 1 was a 10‐year‐old girl with short stature. She was found to have delayed bone age, slow growth velocity, and iron‐deficiency anemia, which was refractory to treatment. Thrombocytosis and hypergammaglobulinemia were later detected. Chest X‐ray revealed a hilar mass. Patient 2 was a 14‐year‐old boy who had severe cough, progressive mucocutaneous erosion, and dermatitis. Chest X‐ray showed a mediastinal mass. Sections of skin biopsy showed findings consistent with pemphigus disease. In each case, the histological diagnosis of Castleman disease was made. Pediatr Blood Cancer 2006; 47:616–620. © 2005 Wiley‐Liss, Inc.

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