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Second and third malignant solid tumor in a girl with ovarian Sertoli–Leydig tumor
Author(s) -
Panagiotou John P.,
Polychronopoulou Sophia,
Sofou Kalliopi,
VanVlietConstantinidou Catherine,
Papandreou Evangelos,
Haidas Stavros
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20486
Subject(s) - medicine , embryonal rhabdomyosarcoma , ovary , rhabdomyosarcoma , immature teratoma , girl , chemotherapy , abdomen , sarcoma , ovarian cancer , radiation therapy , blood cancer , surgery , pathology , germ cell tumors , cancer , psychology , developmental psychology
We report a Sertoli–Leydig cell (SLC) tumor of the right ovary in a 10‐year‐old girl, which was dealt with surgical removal. Three months after resection, she presented with a new episode of acute abdomen because of an abdominal mass, which histologically was compatible with an undifferentiated embryonal rhabdomyosarcoma. Chemotherapy, according to SIOP‐??? 89 protocol, was administered additionally to radiotherapy (3,960 cGy). Three years after completing treatment, the patient developed a painful swelling at her left upper arm. The diagnosis was Ewing sarcoma of the humerus, which was confirmed by identification of the typical 11; 22 translocation on cytogenetic and molecular analysis of the tumor tissue. The patient died 14 months from Ewing diagnosis due to progressive disease. Pediatr Blood Cancer © 2006 Wiley‐Liss, Inc.