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Pulmonary function abnormalities in children treated with whole lung irradiation
Author(s) -
Weiner Daniel J.,
Maity Amit,
Carlson Claire A.,
Ginsberg Jill P.
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20457
Subject(s) - medicine , spirometry , dlco , pulmonary function testing , lung volumes , cohort , diffusing capacity , restrictive lung disease , lung , vital capacity , cumulative incidence , retrospective cohort study , respiratory disease , surgery , lung function , asthma
Background We sought to determine the prevalence of abnormal pulmonary function tests (PFTs) in a cohort of children who had received whole lung irradiation (WLI) for treatment of metastatic disease. Procedure This was a retrospective (1988–2003) chart review that included all children treated at our institution with WLI who had undergone PFT. Data abstracted included oncologic diagnosis, radiation dose and fractionation, spirometry (FVC, FEV 1 , FEV 1 /FVC, FEF 25%–75% ), plethysmography (TLC, FRC, RV, RV/TLC), diffusing capacity (DLCO), and respiratory muscle strength (MIP, MEP). PFTs were normalized according to standard deviation (Z) scores. Results Thirty patients were identified who had one or more PFT. The incidence of mild, moderate, or severe reductions in FEV 1 was 30%, 10%, and 10%, respectively, with 50% having normal FEV 1 . Seventeen percent of patients had mild reduction in total lung capacity (TLC), while 13% and 30% had moderate or severe reductions. Thirty‐eight percent had mild reductions in diffusing capacity, while 29% and 14% had moderate or severe reductions. Conclusions Pulmonary function abnormalities were common in this cohort of children treated with WLI, and may be progressive in nature. Further studies are warranted to identify patients at highest risk. © 2005 Wiley‐Liss, Inc.