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Treatment of Wilms tumor according to SIOP 9 protocol in Casablanca, Morocco
Author(s) -
Madani Abdellah,
Zafad Saadia,
Harif M'hamed,
Yaakoubi Mohammed,
Zamiati Soumaya,
Sahraoui Souha,
Benjelloun Amal,
Fehri Mohammed,
Benchekroun Said
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20436
Subject(s) - medicine , wilms' tumor , abdominal mass , stage (stratigraphy) , surgery , pediatrics , paleontology , biology
Abstract Background Childhood Wilms tumor represents one of the challenge for pediatric oncologists in developing countries. We report the characteristics and treatment results of patients with Wilms tumor according to SIOP 9 protocol in Morocco. Procedure From January 1989 to December 2000, 86 children with Wilms tumor were admitted. The diagnosis was based on physical exam and abdominal ultrasound. The metastatic work‐up was based on abdominal ultrasound and chest X‐ray. Results The mean age was 36 months (3–120 months). The sex‐ratio was 1. Abdominal mass was the main symptom at presentation (84 cases). There were 13 metastatic cases. Treatment applied was according to SIOP 9 Protocol without randomization. Local deases was present in 75 patients with stage I in 38 cases (50%), IIN0 in 4 cases (6%), IIN1 in 9 cases, and III in 24 cases (44%). The distribution of pathologic groups was: favorable in 4 cases, standard in 69 cases, and unfavorable anaplastic type in 2 cases. Sixty‐nine patients were evaluable for therapeutic evaluation. Other patients were lost to follow‐up. Three patients died of treatment related toxicity and 13 patients relapsed. With a median follow‐up of 70 months, the 5‐year EFS and 5 years overall survival for evaluable patients are 77.4% and 79%, respectively while the 5‐year EFS for all patients was 56%. Conclusion These results are encouraging for a developing country but special efforts should be done to reduce the rate of abandonment. Pediatr Blood Cancer 2006, 46:472–475. © 2005 Wiley‐Liss, Inc.