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Multicentric osteosarcoma presenting as retrobulbar mass: A diagnostic enigma
Author(s) -
Wong K.F.,
Shu S.J.,
Luk I.S.C.,
Yuen H.L.,
Leung J.N.S.,
Chan J.K.C.
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20431
Subject(s) - medicine , osteosarcoma , osteoid , biopsy , pathology , lesion , trephine , primary bone , radiology
Osteosarcoma is the most common primary malignant bone tumor of children and adolescents. It often presents as a solitary lesion; multicentric osteosarcoma with synchronous lesions occurring at multiple skeletal sites is very rare. We report a 9‐year‐old boy with multicentric osteosarcoma who presented with a left retrobulbar non‐sclerotic mass. The multiple lesions in bone were mostly non‐sclerotic on radiological examination except for a single lesion in the left tibia. Biopsy of the retrobulbar mass showed an unclassifiable poorly differentiated malignant tumor. Marrow aspiration smears showed many large, often segregated, round cells that expressed NB84a. However, trephine biopsy showed the formation of tumoral osteoid by the malignant cells, finally permitting the definitive diagnosis of osteosarcoma to be made. A hypertetraploid clone with complex structural abnormalities was demonstrated by cytogenetic study. © 2005 Wiley‐Liss, Inc.