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Polymorphism of angiotensin converting enzyme is associated with severe circulatory compromise in febrile neutropenic children with cancer
Author(s) -
Bárdi Edit,
Jenei Csaba,
Kiss Csongor
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20400
Subject(s) - medicine , genotype , angiotensin converting enzyme , polymorphism (computer science) , allele , circulatory system , gastroenterology , intensive care unit , pediatric intensive care unit , allele frequency , gene , pediatrics , genetics , biology , blood pressure
Abstract Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism influences the outcome of a number of cardiovascular diseases. ACE I/D polymorphism was investigated by PCR in 207 pediatric cancer patients and 144 controls. ACE I/D distribution of patients and controls was similar. The frequency of the D allele and the prevalence of the deletion (DD) genotype were significantly ( P < 0.05) higher among patients with severe circulatory compromise requiring treatment in the intensive care unit (ICU) than among the other patients and controls. Patients with the DD and ID genotypes spent significantly ( P < 0.05) longer time in the ICU than patients with the II genotype. © 2005 Wiley‐Liss, Inc.