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Rhabdomyoblastic pulmonary lesions in a patient with Wilms Tumor: choristomas or metastases?
Author(s) -
Zwerdling Ted,
Ducore Jonathan,
Taylor Douglas,
West Daniel C.,
Konia Thomas
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20374
Subject(s) - medicine , wilms' tumor , stage (stratigraphy) , biopsy , pathology , radiology , paleontology , biology
New lesions that occur while patients are receiving treatment for malignant tumors may represent not only difficulties in arriving at the correct diagnosis, but also impact on subsequent therapeutic options. We encountered a patient developing new pulmonary lesions during and after receiving treatment for Stage II Wilms tumor (WT). The presence of mature rhabdomyoblasts in multiple biopsy specimens allowed rational decisions to be made regarding subsequent therapy. This and other published experiences suggest that patients with WT may develop choristomas or have tumors, which undergo cytodifferentiation. Methodologies are now available allowing differentiation of these two processes. © 2005 Wiley‐Liss, Inc.