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Pathology of radiation and anthracycline cardiotoxicity
Author(s) -
Berry Gerald J.,
Jorden Michelle
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20346
Subject(s) - cardiotoxicity , medicine , anthracycline , disease , radiation therapy , cardiology , toxicity , oncology , pathology , cancer , breast cancer
Radiation‐induced heart disease (RIHD) and anthracycline cardiotoxicity are two patterns of cardiac dysfunction caused by therapeutic interventions to treat malignancies. They occur in both the pediatric and adult populations and there is evidence to suggest that pediatric patients are at greater risk. This is due in part to the longer survival rates but also reflects increased susceptibility to the attendant complications caused by both therapies. Radiation can cause injury to all the components of the heart, including the vasculature, while anthracycline toxicity is generally limited to the myocardium. Pediatr Blood Cancer 2005;44:630–637. © 2005 Wiley‐Liss, Inc.