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Immune thrombocytopenia following successful treatment of cancer in children
Author(s) -
Price Victoria,
Barnes Chris,
Canning Patricia,
Blanchette Victor,
Greenberg Mark
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20341
Subject(s) - medicine , immune thrombocytopenia , malignancy , blood cancer , immune system , lymphoblastic leukemia , pediatrics , chemotherapy , cancer , childhood cancer , pediatric cancer , bone marrow , leukemia , immunology , platelet
A predisposition to developing immune thrombocytopenia (ITP) has not been reported in survivors of childhood cancer. We report a case series of childhood cancer survivors who developed an isolated thrombocytopenia in the presence of a normocellular bone marrow. Five children, two with endodermal sinus tumors and three with acute lymphoblastic leukemia, developed ITP at a median of 4 years (range: 0.2–8 years) after completion of therapy. We suggest the association of ITP in survivors of childhood malignancy may not be co‐incidental as chemotherapy may cause persistent immune dysfunction. © 2005 Wiley‐Liss, Inc.
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