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Veno‐occlusive disease of the liver in a child after chemotherapy for brain tumor
Author(s) -
Elli Murat,
Güçlü Pınarlı Faruk,
Daǧdemir Ayhan,
Acar Sabri
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20338
Subject(s) - medicine , medulloblastoma , hepatic veno occlusive disease , chemotherapy , wilms' tumor , vincristine , carboplatin , complication , disease , surgery , oncology , pathology , cyclophosphamide , hematopoietic stem cell transplantation , cisplatin
Veno‐occlusive disease (VOD) of the liver is a life‐threatening state generally occurring as a complication of bone marrow transplantation or chemotherapy for Wilms' tumor. Veno‐occlusive disease after standard dose chemotherapy in malignancies other than Wilms' tumor is rare and only a few cases have been published in children. We report a 19 month‐old‐girl with medulloblastoma who experienced fatal VOD of liver after only one course of chemotherapy including carboplatin, vincristine and CCNU for medulloblastoma. As our knowledge, this is the first report of VOD after standard dose chemotherapy for brain tumor in childhood. Pediatr Blood Cancer 2006,46:521–523. © 2005 Wiley‐Liss, Inc.