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Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith–Wiedemann syndrome with high dose acetaminophen and N ‐acetylcysteine rescue
Author(s) -
Kobrinsky Nathan L.,
Sjolander Diane E.,
Goldenberg Jacob A.,
Ortmeier Thomas C.
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20330
Subject(s) - hepatoblastoma , medicine , acetylcysteine , cisplatin , doxorubicin , acetaminophen , vincristine , chemotherapy , pharmacology , biochemistry , chemistry , antioxidant , cyclophosphamide
Abstract High dose acetaminophen (HDAC) with N ‐acetylcysteine (NAC) has been effective in adults with advanced malignancies. We report HDAC with NAC in a child with progressive hepatoblastoma, confirmed at biopsy of an unresectable hepatic mass. Alpha‐fetoprotein (AFP) increased despite four courses of doxorubicin and one course of cisplatin, 5‐flurouracil, and vincristine. Following HDAC with NAC, AFP markedly decreased. A continued response without toxicity was observed during four subsequent courses of HDAC with NAC and cisplatin. The residual necrotic tumor was resected. The child is now over 8 years disease free. HDAC and NAC are effective and well tolerated for progressive hepatoblastoma. © 2005 Wiley‐Liss, Inc.