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Antioxidant status decreases in children with acute lymphoblastic leukemia during the first six months of chemotherapy treatment
Author(s) -
Kennedy Deborah D.,
Ladas Elena J.,
Rheingold Susan R.,
Blumberg Jeffrey,
Kelly Kara M.
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20307
Subject(s) - medicine , chemotherapy , antioxidant , adverse effect , oxidative stress , lymphoblastic leukemia , vitamin c , vitamin e , vitamin , leukemia , pediatrics , biochemistry , chemistry
Background Children undergoing treatment for acute lymphoblastic leukemia (ALL) receive combination chemotherapy and many of the components are associated with free radical production. Procedure Among 103 children newly diagnosed with ALL, plasma concentrations of antioxidants, total antioxidant capacity (ORAC), and DNA oxidized base 8‐oxodeoxyguanosine (8‐oxo‐dG) were analyzed at baseline and 3 and 6 months after diagnosis. Results Plasma vitamin A, antioxidants, 8‐oxo‐dG, and ORAC changed from diagnosis through the first 6 months of ALL therapy. In patients with higher plasma concentrations of vitamin A, E, total carotenoids, ORAC, and 8‐oxo‐dG there was a beneficial association with fewer dose reductions, fewer infections, improved quality of life, less delay in chemotherapy treatment schedule, reduced toxicity, and fewer days spent in the hospital. There were also adverse relationships demonstrated. Conclusions Among children with ALL, antioxidant levels and oxidative stress appear to be associated with duration and complications of treatment. © 2004 Wiley‐Liss, Inc.