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Cortical laminar necrosis in childhood intracranial germ cell tumor survivors
Author(s) -
Khong PekLan,
Ng KimChing,
Kwong Dora LW,
Ooi GaikCheng,
Chan Godfrey CF
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20270
Subject(s) - medicine , magnetic resonance imaging , necrosis , presentation (obstetrics) , complication , pathology , radiology , surgery
We report two childhood germ cell tumor survivors treated for multifocal or large suprasellar tumors followed by the presentation of acute neurological deficits and extensive cortical laminar necrosis on magnetic resonance imaging (MRI), 7 and 34 months after cranial irradiation. This complication, though uncommon, represents another manifestation of delayed treatment‐related brain injury that can be catastrophic and leads to significant morbidity. © 2004 Wiley‐Liss, Inc.