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Tumor response and toxicity with multiple infusions of high dose 131 I‐MIBG for refractory neuroblastoma
Author(s) -
Howard James P.,
Maris John M.,
Kersun Leslie S.,
Huberty John P.,
Cheng SuChun,
Hawkins Randall A.,
Matthay Katherine K.
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20240
Subject(s) - medicine , toxicity , neutropenia , refractory (planetary science) , neuroblastoma , platelet transfusion , platelet , intravenous infusions , chemotherapy , infusion therapy , gastroenterology , surgery , physics , astrobiology , biology , genetics , cell culture
Abstract Background 131 I Metaiodobenzylguanidine ( 131 I‐MIBG) is an effective targeted radiotherapeutic for neuroblastoma with response rates greater than 30% in refractory disease. Toxicity is mainly limited to myelosuppression. The aim of this study was to determine the response rate and hematologic toxicity of multiple infusions of 131 I‐MIBG. Procedure Patients received two to four infusions of 131 I‐MIBG at activity levels of 3–19 mCi/kg per infusion. Criteria for subsequent infusions were neutrophil recovery without stem cell support and lack of disease progression after the first infusion. Results Sixty‐two infusions were administered to 28 patients, with 24 patients receiving two infusions, two patients receiving three infusions, and two patients receiving four infusions. All patients were heavily pre‐treated, including 16 with prior myeloablative therapy. Eleven patients (39%) had overall disease response to multiple therapies, including eight patients with measurable responses to each of two or three infusions, and three with a partial response (PR) after the first infusion and stable disease after the second. The main toxicity was myelosuppression, with 78% and 82% of patients requiring platelet transfusion support after the first and second infusion, respectively, while only 50% had grade 4 neutropenia, usually transient. Thirteen patients did not recover platelet transfusion independence after their final MIBG infusion; stem cell support was given in ten patients. Conclusions Multiple therapies with 131 I‐MIBG achieved increasing responses, but hematologic toxicity, especially to platelets, was dose limiting. More effective therapy might be given using consecutive doses in rapid succession with early stem cell support. © 2004 Wiley‐Liss, Inc.