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Epstein–Barr virus‐associated peripheral T‐cell lymphoma and hemophagocytic syndrome arising after liver transplantation: Case report and review of the literature
Author(s) -
George Tracy I.,
Jeng Michael,
Berquist William,
Cherry Athena M.,
Link Michael P.,
Arber Daniel A.
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20231
Subject(s) - medicine , lymphoma , lymphoproliferative disorders , transplantation , epstein–barr virus , epstein–barr virus infection , virus , herpesviridae , immunology , liver transplantation , hemophagocytic lymphohistiocytosis , gammaherpesvirinae , pathology , viral disease , disease
Post‐transplantation lymphoproliferative disorders (PTLD) are a well‐recognized complication of solid organ transplantation. The vast majority of PTLD are Epstein–Barr virus (EBV)‐related infections that manifest as B‐cell malignancies. We report an unusual case of an EBV‐associated T‐cell lymphoma in a 10‐year‐old boy who had previously undergone liver transplantation at age 4 years. He presented with hemophagocytic syndrome (HPS) and active EBV infection, with positive serum titers and polymerase chain reaction (PCR) for EBV in blood, colon, and antral samples. © 2004 Wiley‐Liss, Inc.