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Successful engraftment following unrelated donor transplant in an alloimmunized patient with Kostmann syndrome
Author(s) -
Myers Scott N.,
Zeevi Adriana,
Zorich G. Phil,
Pillage Gina,
Martel Joan,
Goyal Rakesh K.
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20230
Subject(s) - medicine , neutropenia , refractory (planetary science) , congenital neutropenia , histocompatibility testing , bone marrow , graft versus host disease , human leukocyte antigen , transplantation , surgery , immunology , chemotherapy , antigen , physics , astrobiology
Severe chronic neutropenia (SCN) is characterized by severe recurrent bacterial infections during infancy. Blood or marrow transplantation (BMT) is the only curative option for patients with refractory disease. This report describes the case of a 4‐year‐old girl with refractory SCN, who received a bone marrow transplant from a highly matched donor after becoming HLA sensitized to multiple granulocyte transfusions. She is clinically well with normal blood counts and stable mixed chimerism 3 years after BMT. She experienced no graft rejection or graft versus host disease. © 2004 Wiley‐Liss, Inc.