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Mucoepidermoid carcinoma of the parotid gland in a child previously treated for acute lymphoblastic leukemia
Author(s) -
BocconGibod Liliane,
Boman Françoise,
Josset Patrice,
LandmanParker Judith
Publication year - 2004
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20188
Subject(s) - medicine , mucoepidermoid carcinoma , lymphoblastic leukemia , parotid gland , leukemia , carcinoma , pathology , oncology
Occurrence of second cancers is a major concern for the care of children cured of cancer. Children treated for acute lymphoblastic leukemia (ALL) have an increased risk for developing mucoepidermoid carcinomas (MEC) of the parotid gland. The latent period ranges from 5 to 16 years. A 3‐year‐old boy presented with pre‐B ALL. Treatment included multidrug chemotherapy and prophylactic intrathecal injections of methotrexate and prednisolone. Low‐grade MEC of the left parotid gland was diagnosed at the age of 7 years, only 1 year after completing treatment. Local lymph nodes were not metastatic, and course was favorable 8 years after complete surgical excision. This case report is remarkable for the early diagnosis of second cancer, only 4 years after diagnosis of ALL, and its occurrence in parotid gland without previous head and neck irradiation. It highlights the need for concern about second cancers of the parotid gland in children treated for ALL. Pediatr Blood Cancer 2005;44:673–675. © 2004 Wiley‐Liss, Inc.