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Characterization of karyotypic events and evolution in neuroblastoma
Author(s) -
Betts David R.,
Cohen Ninette,
Leibundgut Kurt E.,
Kühne Thomas,
Caflisch Ueli,
Greiner Jeanette,
Traktenbrot Luba,
Niggli Felix K.
Publication year - 2005
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20179
Subject(s) - neuroblastoma , karyotype , cytogenetics , fish <actinopterygii> , biology , molecular cytogenetics , correlation , evolutionary biology , genetics , chromosome , gene , cell culture , geometry , mathematics , fishery
Background Neuroblastoma (NB) is cytogenetically characterized by a number of non‐random events. However, knowledge is limited concerning the timing of occurrence and inter‐action of many of these events. Methods Karyotypic patterns were obtained from a study group of 49 NB tumors that had been analyzed by conventional cytogenetics combined with FISH and in some instances SKY. Results All chromosomes were involved in a numerical and structural aberration in at least one tumor. There was a positive correlation between the occurrence of MYCN and del(1p) and between del(1p) and 17q. Aberrations involving chromosomes X, 3, 19, and del(1p) could be considered early events, whereas those involving chromosomes 9, 13, 15, 18, 20, and 21 were often late events. Conclusions This study suggests that the karyotypic patterns characterizing NB are complex. There are aberrations that can be grouped into early or late karyotypic events, but others, such as gain of 17q, are variable. © 2004 Wiley‐Liss, Inc.