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Adenocarcinoma of the cervix and vagina in pediatric patients
Author(s) -
McNall René Y.,
Nowicki Philip D.,
Miller Brigitte,
Billups Catherine A.,
Liu Tiebin,
Daw Najat C.
Publication year - 2004
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20113
Subject(s) - medicine , vagina , pelvic exenteration , diethylstilbestrol , cervix , clear cell adenocarcinoma , adenocarcinoma , hysterectomy , radiation therapy , in utero , mesonephric duct , surgery , gynecology , cancer , pregnancy , fetus , estrogen , biology , genetics , kidney
Here we report our combined analysis of vaginal mesonephric adenocarcinoma (MA) in a 13 years old treated at our institution and of reported vaginal or cervical MA and clear‐cell adenocarcinoma in 37 patients 18 years old or younger. Tumors in 27 patients arose in the vagina; 8 (21%) had metastases at diagnosis. The predominant symptom was vaginal bleeding; 62% of patients were exposed to diethylstilbestrol in utero. The 3‐year survival estimate was 71% ± 11%. Surgical treatment and metastasis at diagnosis were significant predictors of survival. The association between tumor excision and excellent outcome suggests that radical hysterectomy or pelvic exenteration is unnecessary. Radiotherapy as an adjunct may have contributed to this outcome. © 2004 Wiley‐Liss, Inc.