Premium
Mondini dysplasia and recurrent bacterial meningitis in a girl with relapsing Langerhans cell histiocytosis
Author(s) -
Kitazawa Katsuhiko,
Matsumoto Marika,
Senda Masayoshi,
Honda Akihito,
Morimoto Noriko,
Kawashiro Nobuko,
Imashuku Shinsaku
Publication year - 2004
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20057
Subject(s) - medicine , langerhans cell histiocytosis , girl , meningitis , histiocytosis , dermatology , dysplasia , pathology , pediatrics , disease , psychology , developmental psychology
We report a case of a girl with Langerhans cell histiocytosis (LCH) of multifocal bone disease, who developed recurrent bacterial meningitis and unilateral sensorineural hearing loss during the relapsing course of the disease. Mondini dysplasia, a congenital inner ear anomaly, was suspected by high resolution computed tomographic scan and the dysplasia with cerebrospinal fluid leakage was confirmed by surgery in the ipsilateral ear showing hearing loss. Although rare, congenital inner ear anomalies such as Mondini dysplasia should be kept in mind in pediatric patients with hearing impairment and/or recurrent bacterial meningitis during chemotherapy for various types of neoplasms including LCH. © 2004 Wiley‐Liss, Inc.