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Clinical features and treatment outcomes of 79 infants with immune thrombocytopenic purpura
Author(s) -
Sandoval Claudio,
Visintainer Paul,
Ozkaynak M. Fevzi,
Tugal Oya,
Jayabose Somasundaram
Publication year - 2004
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.10458
Subject(s) - medicine , thrombocytopenic purpura , pediatrics , asymptomatic , incidence (geometry) , odds ratio , purpura (gastropod) , retrospective cohort study , platelet , ecology , physics , optics , biology
Background To determine the clinical features and treatment outcomes of infants with immune thrombocytopenic purpura (ITP). Methods Retrospective analysis of 79 infant ITP patients treated from 1987 to 2002. The data abstracted comprised age, gender, clinical features, and treatment outcomes. A score test for the trend in the odds ratios was used to determine the risk of chronic ITP with advancing age. The infants were compared to a group of contemporaneous older children with regard to bleeding severity and incidence of chronic ITP. Results The 34 female and 45 male infants had a median age of 16 months. Seventy‐four presented with purpura, four with viral illnesses, and one was asymptomatic. Eight percent had active mucosal bleeding. The median platelet count was 8,000/μl. Forty infants received intravenous immunoglobulin, nine intravenous anti‐D immunoglobulin, six steroids, and seven were observed without treatment. Fifty‐five (76%) responded to a single course of treatment. Only 9% of infants developed chronic ITP compared to 18% of children between the ages of 25 and 119 months and 47% of children 120 months or older ( P < 0.0005). Conclusions Infants with ITP respond favorably to treatment and are less likely to develop chronic ITP compared to older children. © 2003 Wiley‐Liss, Inc.