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Association of cytogenetic abnormalities with detection of BCR‐ABL fusion transcripts in children with T‐lineage lymphoproliferative diseases (T‐ALL and T‐NHL)
Author(s) -
Lo Nigro Luca,
Sainati Laura,
Mirabile Elena,
Lanciotti Marina,
Poli Amelia,
Leszl Anna,
Basso Giuseppe
Publication year - 2004
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.10453
Subject(s) - lineage (genetic) , lymphoproliferative disorders , medicine , minimal residual disease , abl , clone (java method) , fusion gene , chromosomal translocation , breakpoint cluster region , cancer research , lymphoma , immunology , biology , genetics , gene , bone marrow , receptor , tyrosine kinase
Detection of Philadelphia chromosome (Ph) in childhood T‐lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T‐ALL and T‐NHL) presenting with both cytogenetic alterations and BCR‐ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi‐lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T‐cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR‐ABL fusion transcript. © 2003 Wiley‐Liss, Inc.